Sentence examples for probability of linkage from inspiring English sources

Calculating a so called LOD score (LOD = logarithm of the odds), can help as a measure of probability of linkage between a variant and a disease.

Here, we applied the posterior probability of linkage (PPL), a method designed specifically to analyze multiple heterogeneous data sets, to the Autism Genetic Resource Exchange collection of families by analyzing six clinically defined subsets of the data and updating the PPL sequentially over the subsets.

Our results indicate a substantial probability of linkage to chromosome 1, which had been previously overlooked; our findings also provide a further characterization of the possible parent-of-origin effects at the 17q11 locus that were previously described in this sample.

As pairwise distance between couples' sequences increased, the Bayesian posterior probability of linkage decreased rapidly, with the majority of couples' pairwise distances associated with posterior probabilities approaching 1 (100% probability of linkage) or 0 (0% probability of linkage) (Figure 4).

We analyzed sequences with phylogenetic techniques and developed a Bayesian algorithm to evaluate the probability of linkage.

We developed a Bayesian algorithm to derive an estimate of the probability of linkage between sequences in our cohort based on the reference datasets of pairwise genetic distances for epidemiologically and phylogenetically linked and unlinked individuals described above.

P linked) and P unlinked) are the prior probabilities of linkage and lack of linkage for pairs of sequences from HIV-1 infected partner participants in our dataset and f(X | linked) and f(X | not linked) are conditional densities of the genetic distances for linked or unlinked sequences based on the distribution of genetic distances in the reference datasets.

Here, an initial value of P linked) is chosen (P linked)  = 0.5), the posterior probabilities of linkage for each couple is computed, and P linked) is updated as the proportion of partners who are classified as linked in the Partners in Prevention HSV/HIV Transmission Study.

The LLS was calculated based on the prior odds (OPrior), describing the ratio of probability of functional linkage and its negation without evidence, and the posterior odds (OPosterior), describing the ratio of probability of functional linkage and its negation under the given evidence.

Slatkin [ 43] demonstrated that the probability of detecting linkage disequilibrium between (neutral) loci in mtDNA is greatly diminished in a population that recently expanded.

Additionally, the density of SNPs selected within genes for this analysis suggests high probability of genetic linkage, and it is possible that some of the associations we observed may be markers of other functional regions.