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Finally, since there is always a non-null probability of incorporating points in the tails,15 thus implying that (D_{mathcal {I}_{t}^{c}}(pi,q_{t}) to 0) as t→∞, since (mathcal {I}_{t}^{c}) becomes smaller and smaller as t increases.
We found that the greater the distance between the mutation and the cassette insertion, the lower the probability of incorporating the mutation.
The probability of incorporating the targeted mutation in gsSSG mutagenesis decreases as the distance between the insertion site and the targeted mutation increases but remains efficient at least 460 bp on either side of the insertion site.
We hypothesized that decreasing the starting concentration of homotetramer 5 [FTTR]T TTrelativeive to that of homotetramer 1 (untagged WT TTR) would lower the probability of incorporating FT2·WT TTR subunits into tetramers 2 4 during subunit exchange.
For a mutation rate μ, the probability that a sequence of length l acquires k mutations upon replication follows a Poisson distribution of average μl, (4) The probability of incorporating no mutations is thus P 0) = e- μl, which for μl ≪ 1 reduces to P 0) = 1 - μl.
The expected relative area of tetramers 1 5 at equilibrium is predicted by a binomial distribution, where n = 4, k is the number of untagged TTR subunits in the peak of interest, and p is the probability of incorporating an untagged TTR subunit, which is the fraction of untagged TTR relative to total TTR, which equals [ area of peak 1 at time zero)/ total area of peaks 1 5 at time zero)].
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Thus, the probability (p) of incorporating an untagged subunit into any tetramer is directly proportional to the relative abundance of untagged TTR.
We reasoned that two non-conjugated FRET partner molecules with the affinity for β sheets would, upon mixing with the Aβ species (aggregates, fibrils and plaques), have a high probability of randomly incorporating themselves into the Aβ species within10 nm proximity to generate a viable FRET signal (Fig. 1).
Together, the transition rates for these processes determine the net probability of stably incorporating the rNMP.
Summary of effects of 224 markers that had the largest posterior probability of being incorporated in the model for each trait.
Genes located relatively close to each other in the nuclear space have a greater probability of being incorporated into the same transcription factory [ 67, 68].
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