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The model considers the probability of duplicate packet generations.
The duplication degeneration complementation model of gene duplication (Force et al. 1999) predicts that degenerative mutations in regulatory elements can increase (rather than reduce) the probability of duplicate gene preservation and predicts that the usual mechanism of duplicate gene preservation is the partitioning of ancestral functions rather than the evolution of new functions.
According to the duplication-degeneration-complementation (DDC) model [35] degenerative mutations in regulatory elements can increase the probability of duplicate gene preservation and the mechanism of preservation of duplicate genes is partitioning of ancestral functions.
To reduce the probability of duplicate sampling, sampled individuals were separated by a minimum of 10 m.
It has also been proposed that one of the factors influencing the probability of duplicate gene retention is its connectivity [ 22].
In the case of P. trichocarpa, the negative degree centrality coefficient leads to an inverse relationship between connectivity and the probability of duplicate retention in the presence of few duplicated neighbors.
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For our null hypothesis, we assumed that each chromosome has an equal probability of duplicating or splitting and an equal probability of being lost at any time.
Although probabilities of duplicates acquiring novel and beneficial functions is lower than duplicates being silenced [ 3], the classical model of the fates of duplicate genes proposed by Ohno is coming under increasing scrutiny [ 4- 6].
Here, we have shown that the topological properties of ENTS-predicted networks, including the first whole-genome interactome for P. trichocarpa, are related to the probability of WGD duplicate gene retention following independent duplication events in a manner consistent with the predictions of the gene balance hypothesis.
However, if the duplicate is not the top-most related article, there is a low probability of the duplicate appearing in PubMed's related article list (data not shown).
The evolutionary significance of gene duplication is explained by the duplication-degeneration-complementation (DDC) model, which states that the probability of a duplicate gene to be preserved increases with the occurrence of degenerative mutations in its regulatory region [36].
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