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The magnetic conditions at the location of this profile are unlike those experienced by the other profiles: the magnetic field is relatively strong and field lines have a relatively high probability of being open.
With fixed level of intracellular Ca2+ [Ca2+]i, BKCa channels behave like delayed-rectifier K+ channels, activating with depolarization where the gating rates and the resulting probability of being open are also sensitive functions of [Ca2+]i.
Based on these observations, we suggest that the appearance of rectification and substates of BK-type channels arise from a reduction of the cooperativity among these four residues and a lower probability of being open.
If Phe508del-CFTR is expressed at the apical membrane — for example, following monotherapy with a CFTR corrector such as lumacaftor — it has been demonstrated that the chloride channel has a reduced probability of being open, operating as a class III gating CFTR mutation [ 15, 16].
This provides an explanation for the disappointing results associated with lumacaftor monotherapy in patients who are homozygous for the mutation [ 68] — if Phe508del-CFTR is expressed at the apical membrane, the chloride channel still has a (reduced) probability of being open [ 15, 39].
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A multiple logistic regression model was fit to predict the probability of being opened for ongoing services at the conclusion of maltreatment-related investigations involving infants using clinical concerns as predictors.
This threshold is chosen so that the inferred probability of chromatin being open is close to 1 according to our model.
Many of these modulatory proteins can prevent or ameliorate the probability of the channel being open, thereby contributing directly to cardiac contraction.
It has been suggested that the channel conductance or the probability of a channel being open is likely to be dependent on the sixth transmembrane helix of ChRs [23].
From this large observational study based on linked administrative health records taking into account the disomogeneous distribution of factors related to the probability of being offered open surgery people who end up having an LC have a better short-term prognosis than those who get an OC for the treatment of gallstones.
However, submicromolar cytosolic Ca2+ levels increase the probability of the channel being open with high-affinity binding sites available.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com