In silico models suggest that exposures produced by infusions of β-lactam antibiotics generate a greater probability of target attainment than those attained with bolus dosing (13).
Fig. 1 Correlation between Parental Education and Educational Attainment (Gamma coefficient) vs. Probability of Attaining Higher Education Level than Parents with no Tertiary Education (Median lines superimposed).
For the illustrative example, the probability of target attainment with imperfect adherence (Pip) was 0.38 and the probability of target attainment with perfect adherence (Pp) was 0.62 yielding a relative forgiveness (RF) of 0.38.
In such cases, economic sanctions often provide a policy alternative with modest expectations of goal attainment at relatively low cost, while military force involves a higher probability of goal attainment accompanied by much higher costs.
A general form of a relative forgiveness is given by, : 1where is the relative forgiveness, is the probability of successful attainment of a treatment target under imperfect adherence, and is the probability of successful attainment of a treatment target under perfect adherence.
Probability of target attainment efficacy/toxicity.
Unlike with intermittent administration, continuous infusion provided a probability of target attainment of 100%, regardless of age and weight.
The aim of this study was to compare the probability of target attainment (PTA) and the cumulative fraction of response (CFR) for meropenem between administration by bolus injection and a 3-h infusion.
Indeed, for an intermittent bolus administration, a 4gx4 dose is associated with a very low probability of target attainment, even for the lowest PK/PD target of T > MIC = 50%[32]].
