The probability of attainment (PTA) of optimal Cpeak/MIC was calculated using the initial Cpeak for a wide range of MICs (0.5 to 16 mg/L).
However, the probability of attainment of a performance level is implicitly considered in the code design approach (provisions and requirements); for instance, the minimum requirements in concrete structures cannot be simply correlated to the probability of collapse of the building as well as to its overall structural response.
For piperacillin, the probability of target attainment for at least 50% of free drug T > MIC was at least 91% for doses of at least 4.5 g every 8 h at MICs of 16 μg/ml or less [10 ▪].
However, it is important to note that most studies [ 28- 31] demonstrated a poor probability of target attainment for the levofloxacin 500 mg QD regimen when MICs are 1 mcg/ml or more.
The probability of target attainment for Candida albicans, C. glabrata, C. krusei, C. parapsilosis, C. tropicalis, Aspergillus fumigatus, A. niger, and A. terreus were evaluated for a goal fAUC/MIC >25 or >35 at a voriconazole loading dose of 6 mg/kg IV every 12 hours and maintenance dosages of 4 and 6 mg/kg every 12 hours.
The big challenge, however, has been the drive for attainment.
Assurance of the population access to quality PC service is important for attainment of the MDGs.
For tazobactam, the probability of target attainment was 57, 84, and 94% for doses of 4.5, 6.75, and 9.0 g every 8 h, respectively [10 ▪].
A population PK model was constructed, and the probability of target attainment (PTA) for 50% and 100% fT>MIC was calculated for varying MIC and CLCR values.
Indeed, for an intermittent bolus administration, a 4gx4 dose is associated with a very low probability of target attainment, even for the lowest PK/PD target of T > MIC = 50%[32]].
