Patients with precancerous lesions such as leukoplakia and erythroplakia have a high probability to progress to carcinoma without early diagnosis.
Epidemiological studies have identified that melanoma is a lethal type of skin cancer because of its relatively high probability to progress to metastasis and its resistance to chemotherapy.
Allowing for the fact that colorectal microadenomas probably vary in their progression to macroscopic lesions (Crabtree et al, 2001), this finding raises the possibility that increased Wnt activation in MCRA leads microadenomas more rapidly or with greater probability to progress to macroadenomas.
In the Netherlands, for example, it would apply to about half of the women attending screening around age 50. 10 Because there is strong evidence that cervical intraepithelial neoplasia lesions have a higher probability to progress to invasive cancer at older ages, 11 12 a lower detection rate after age 50 alone does not represent conclusive evidence for lower screening efficiency.
An alternative regression method that accounts for the probability to progress to the specific CKD stage of interest between the last measurement of renal function and death or latest follow-up on vital status, is the illness-death model for interval-censored data [ 5, 24].
Transition probabilities allows different patients to progress at different rates.
(V DMSA uptake in HUT seems to be related to Ki-67 activity and could be a useful indicator of the probability of these lesions to progress to atypical hyperplasia, ductal carcinoma in situ or invasive tumors.
Previous studies showed that model parameters, such as test sensitivity, mean duration of the preclinical phase of cancer, and probability of preclinical DCIS to progress to invasive cancer or to regress, can be interchanged to some extent (32) (R. de Gelder, Erasmus MC, Department of Public Health, unpublished manuscript).
Bansal et al. [ 8] justified this low tendency to progress with the probability that the cells already present at the interface have limited proliferating potential and die after a few mitotic divisions, leaving amorphous debris seen clinically as a homogeneous white mass.
"Nothing seems to progress".
