Sentence examples for probabilities to interact from inspiring English sources
Only one of the three domains of SGS1, PF00570 (HRDC domain), has high probabilities to interact with two domains of TOP1: PF01028 (Eukaryotic DNA topoisomerase I catalytic core domain) and PF02919 (Eukaryotic DNA topoisomerase I DNA binding domain).
We further illustrated usefulness and utility of DRABAL through screening FDA approved drugs and reported ones that have a high probability to interact with several targets, thus enabling drug-multi-target repositioning.
The assumption behind our method is that a drug and a protein have a higher probability to interact if there are more paths connecting them as the paths represent confident relationships between the nodes.
The probability to interact with more than five targets was only ~8%.
An active PubChem compound displayed a ~50% probability to interact with two or more targets.
The analysis suggests that all proteins have a more or less strong probability to interact.
Furthermore, the probability of promiscuity of approved drugs from DrugBank is ~84% and the probability to interact with more than five targets still ~37%.
The genes in an operon tend to be co-expressed [ 1, 2] and their protein products have higher probability to interact with each other [ 3, 4].
In addition to separating cellular volumes, membranes confine the space available to membrane-associated proteins to two dimensions (2D), which greatly increases their probability to interact with each other and assemble into multiprotein complexes.
Interprosurf server was used to reveal the surface residues of mortalin, Bcl-2 and Bcl-xL protein structures with high probability to interact with other proteins (Supplementary Table S1 available at http://www.bioscirep.org/bsr/033/bsr033e073add.htm).htm
Because the farnesylated Tβγ is predominantly localized at the cytoplasmic surface of the disk membranes, the farnesylated Tβγ may have higher probability to interact with PE and PS rather than with PC, PIP2, and SM.
