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RR will be calculated as the ratio between the probabilities of side effects in the TPM group with respect to the control group.
One would expect that a small probability of benefit and large probabilities of side effects would call for the input of the patient in the process of decision-making.
The TTM presented sequentially a short description of the two treatments and the respective probabilities of side effects as had been established at 2-year (sexual dysfunction; Marijnen et al, 2005) and 5-year (incontinence; Peeters et al, 2005) follow-up.
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Patients who received antivirals had a probability of side effects [mainly gastrointestinal with attendant quality-adjusted life year (QALY) decrements].
The probability of side effects and study withdrawal can be reduced by this procedure.
NTCP modelling in radiation therapy aims to describe the correlation between dosimetric parameters and the probability of side effects [ 8– 10].
Finally, while we included the cost of dialysis side effects, we did not model it through the probability of side effects due to availability of patient-level data.
The expected survival benefit of definitive PCa therapy must therefore also be balanced against the associated probability of side effects, including urinary incontinence and erectile dysfunction.
Statistically, there were no differences between our two groups due to our small sample sizes and the low probability of side effects.
In order to optimise the balance between increased probability of side effects and improved target volume coverage, we tested a sentinel node based IMRT approach.
RR will be calculated as the ratio between the probability of side effects in the propranolol group with respect to the control group.
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