If we aim for a RRR >20% or >25%, all probabilities of benefits become lower independent of the degree of skepticism.
For any public health intervention, probabilities of benefits and risks must be balanced.
As outlined in the study protocol, risk comprehension was operationalised by the level of patient knowledge and understanding of the notion of risk, individual heart attack risk, and probabilities of benefits and harms of preventive treatment options, including realistic expectations.
Further objectives are to assess if the ISDM group achieves a better understanding and higher levels of realistic expectations regarding heart attack risk and probabilities of benefits and harms of preventive options.
A description of the options, probabilities of benefits and harms for each option, and video-clips of patient experiences allows patients to clarify their values associated with outcomes of options.
Successful SDM can only be achieved if patients understand disease risks and probabilities of benefits and harms of healthcare options and interpret them in a realistic way [ 10, 12, 21, 22].
Conversely, patients whose life expectancy is less than three to five years (that is, less than the time lag to an absolute risk reduction of one in 5000) probably should be discouraged from screening, since the potential risks probably outweigh the small probability of benefit.
The benefit of a diagnostic imaging should be estimated by its diagnostic efficacy that is "the probability of benefit to individuals from a system or test under ideal conditions of use" (Rosen et al. 2015; Krupinski and Jiang 2008).
We show that, with the sample size achievable in the Neonatal Network, Bayesian analyses are likely to provide clear and clinically useful assessments of the probability of benefit for all important clinical outcomes resulting from initial feeding regimens for ELBW infants.
