Two randomized phase 3 trials of ipilimumab in advanced melanoma have reported overall survival benefit over control arms, with a side-effect profile that was managed with proactive treatment guidelines as outlined in the individual protocols 22– 22.
Historically, the four major sports leagues have become increasingly proactive in instituting guidelines for suspensions for using illegal substances (which can be categorized as self-destructive behavior), in contrast to baby steps in dealing with destructive behavior toward others.
Consequently, it was proposed that proactive diarrhoea management guidelines that stress the importance of early detection and active symptom control could improve tolerability, increase dose intensity and improve efficacy (Wadler et al, 1998; Kornblau et al, 2000; Benson et al, 2004), as has been shown for irinotecan (Abigerges et al, 1994).
Authors of IPD meta-analyses need to be more proactive in making guideline developers aware of new results.
The analysis developed in this paper can help gain insight into the effect of group mobility on the performance of MANET proactive routing, and provide guidelines for designing appropriate routing techniques for MANETs with swarm mobility patterns.
15 UK guidelines recommend proactive targeting of disadvantaged women to improve maternal and infant nutrition outcomes.
The six variables were selected by an à priori approach based on factors considered as relevant in the guidelines for proactive follow-up after the attack.
Importantly, Aboriginal organisations must be proactive in defining reasonable guidelines for engagement, illustrated through organisation policies outlining partnership terms and conditions, to assist laying foundations of inter-service collaborations that will meet their values, interests and concerns.
This has generally been attributed to a lack of career-boosting incentives for researchers to contribute to community annotation efforts (16); however one study suggests that intuitive interfaces, clear annotation guidelines and proactive solicitation of community contributions are more important factors than incentives (18).
