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Baudrillard follows here the poststructuralist critique that thought and discourse could no longer be securely anchored in a priori or privileged structures of "the real".
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In a first application, the method identified a molecular scaffold as a potentially privileged structure of druglike compounds for chemoresistant tumor therapy [1].
In view of the importance of imidazo[1,2-b][1,3]thiazole imidazo[1,2-b][1,3]thiazoleiandazole as privileged structures for the preparation of novel anticancer agents, we decided to explore the synthesis asd biological evaluation of molecular conjugates comprivilegedestructuresicyclic systems tethered at their C-6 position by a meta-(α-bromoacryloylamido)phenyl moiety.
The interest in 8-hydroxyquinolines has grown exponentially in the last two decades as they are privileged structures for the design of new drug candidates that exert a host of biological effects on various targets.
1,4-Dihydropyridines are regarded as privileged structures for drug design, i.e. they tend to bind to a wide variety of receptor sites.
New drugs introduced to the market every year represent privileged structures for particular biological targets.
Herein, we confirm that, like MP, MitP is a privileged structure for the development of antimicrobial peptides active against both prokaryotic and eukaryotic pathogens.
In recent years, many research groups have explored monochloro- or dichloro-phenylpiperazine as a privileged structure for the optimization of CNS-active compounds providing with such psychotropic drugs as aripiprazole, trazodone, cariprazine [9 12] (Fig. 1).
Herein, we further explore LA as a privileged structure for developing multimodal compounds to investigate AD.
The indolin-2-one core is a privileged structure for antitumor agents, especially kinase inhibitors.
In previous studies we described the development of novel spirocyclic HDAC inhibitors based on the combination of privileged structures with hydroxamic acid moieties as zinc binding group.
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