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Precursor cells in the adult SGZ are located in a privileged niche with a distinct cellular composition that controls stem cell activity [58], [25].
However, it can rather be viewed essentially as an intracellular pathogen if one considers that human epithelial cells are the privileged niche for multiplication, and human oral mucosa as the pathogen's primary reservoir [13], [18].
Thus, possible bacterial adaptation during the first infection is unlikely and the variance must result from small numbers of 'founder' bacteria from a privileged niche.
The lack of immune selection on the organism suggests that S. Typhi predominantly occupies an privileged niche within the host, a predominantly intracellular pathogen that can survive for long periods in this state.
Indeed, applying this treatment on fossil bones, they have demonstrated the presence of a privileged niche containing DNA in a better state of preservation than DNA extracted from the total bone.
Selective ablation of macrophages or neutrophils in the zebrafish model has revealed that neutrophils are most likely to form the privileged niche responsible for disseminated infection of S. aureus (Prajsnar et al., 2012).
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Furthermore, Tregs provide an immune-privileged niche in the BM, protecting HSPCs from immune destruction.
Inside Niche.
Our studies revealed a strategy of immune evasion by MNV via the induction of a CD8+ T cell program normally reserved for latent pathogens and persistence in an immune-privileged enteric niche.
Indeed, there is much in Nursery University that may cater to a niche market seeking privileged parenting porn.
Quantitative analysis has revealed that the stem cells are in continual neutral competition with each another to retain a privileged position within the crypt base niche; on average, each stem cell division results in loss and replacement of an individual stem cell lineage (Kozar et al., 2013; Lopez-Garcia et al., 2010; Snippert et al., 2010).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com