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Neonatal porcine Sertoli cells (NPSC) are immune privileged cells showing innate phagocytic and antibacterial activities.
Therefore, speeding the cell cycle up could induce the emergence of privileged cells [ 7].
Guo et al. named these cells privileged cells for pluripotent reprogramming.
For several years, BMMSCs have been considered as immune privileged cells, unable to induce alloreactivity in humans.
They demonstrated that privileged cells have an ultrafast cell cycle (~8 h) and can be synchronously reprogrammed with a short latency [ 7].
An additional property of MSCs is their status as immune privileged cells with low expression of MHC II [ 33, 34] and an absence of co-stimulatory molecules [ 21, 35].
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The embryonic origin of HESC-derived RPE may reflect a more immune privileged cell type in comparison to iPS-RPE, which contributes to their longer-term survival after xenografting.
Excitingly, they identified a special cell state known as the "privileged" cell state that is more amenable to non-stochastic and highly efficient reprogramming.
Adult tissue-derived mesenchymal stem cells (MSCs), though limited in differentiation/expansion potential, are immune-privileged cells that are currently being used in a large number of clinical trials and applications.
These privileged somatic cells exhibit ultrafast cell duplication and express higher levels of proteins involved in DNA repair, RNA processing and cell cycle control (Guo et al., 2014).
Accordingly, the term "privileged somatic cells" for partially pluripotent-committed MEFs seems controversial [ 111].
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