We suggest prioritizing study end points that relate better to the mode of action of immunosuppressive drugs in proof-of-concept trials, i.e. biomarkers of autoimmunity and repeat kidney biopsy to first demonstrate drug efficacy on the underlying systemic disorder and immune complex disease (Table 5).
To arrive at rational pretrial estimates, one can use the modeling and simulation approach to simulate systemic exposure of approved drugs in the three trimesters and postpartum, and based on this, one can optimize design of "first in pregnancy" PK study including prioritizing study period and dosage selection.
The Fallback bargaining and the Borda Scoring algorithms were also selected to prioritize study sub-watersheds based on weighted grades of total score for each variable.
It's important, of course, to prioritize study participants' well-being.
The HEP SC prioritized study findings for dissemination, identified media through which to reach these audiences (e.g., local newspapers, community forums, newsletters), and will participate actively in dissemination of results through these venues.
Despite the prevalence of mold and other toxicants in substandard or poorly maintained tribal homes, neither the Native American Indian Housing Council, a tribal-housing advocacy group based in Washington, DC, nor the Indian Health Service, a division of the U.S. Department of Health and Human Services, has prioritized study of the relationship between indoor air quality and human health.
We'll celebrate with our families, who supported us in this journey; with our friends, who stood by us even when we prioritized studying over socializing; and, of course, with each other.
Researchers and funding agencies should prioritize studies that can help to definitively guide care in these situations.
We elucidate the step-by-step guidelines used to critically prioritize studies from public archives and their metadata curation and discuss the key challenges encountered.
To facilitate the dissemination of evidence, journal editors may want to consider how to prioritize studies of adaptation interventions alongside studies establishing harm and to require adherence to established reporting guidelines.
We present here recommendations, as guidelines, for prioritizing relevant studies and a step-by-step protocol for metadata curation.
