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Here, we adopted a different approach by prioritizing specificity over sensitivity.
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I tend to prioritize specificity (whether the papers I find are on target for me) and accept lower sensitivity (I'm not going to find everything that could potentially be relevant).
If one considers the nature of the instrument and potential consequences of WHO not being aware of an EID event of international public health concern, sensitivity should be prioritized over specificity.
Thus, in this study, sensitivity has been prioritized over specificity, as it is our belief that it is important to be aware of what problems patients with carcinoid tumours may be presented with, and which of these problems patients report as being the worst.
Using a more ad hoc approach of prioritizing the maximization of specificity (due to the relatively rare incidence of OP cancer), we found that a cut-point of >37.43 had a sensitivity of 75.0% and a specificity of 99.3%.
We have chosen to prioritize a high specificity in the tests in an attempt to capture the impaired function in question and to avoid false positive outcomes.
Although the high stringent cut-off value (mean + 3 SD) might prioritize the test specificity and compromise the test sensitivity, the preliminary study in a clinical setting demonstrated that the assays based on both antigens could discriminate positive herds from negative herds.
Prioritizing the Alternatives.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com