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For this reason, a means of prioritizing candidate genes for ASD would help filter out false-positive results and allow researchers to focus on genes that are more likely to be causative.
This compilation and synthesis of data from martian localities indicating hydrothermal activity is timely and a first step towards prioritizing candidate targets for further investigation, which will likely add more targets to this list.
The OPRM1 gene ranks highly on all three criteria introduced for prioritizing candidate genes in association studies investigating pain, namely: strength of evidence supporting involvement in pain sensitivity, frequency of the specific variant, and evidence for functional consequence of the SNP [26, 30].
Recently, computational methods for prioritizing candidate genes have been proposed.
Similarly, Köhler et al. (2008) developed GeneWanderer, a method for prioritizing candidate genes by the use of the random walk analysis that defined similarities in protein-protein interactions (PPI) networks [3].
Results: We propose the first combinatorial approach for prioritizing candidate genes.
This is expected to increase the power of prioritizing candidate genes to a relevant query disease.
The phenotype similarity profile of diseases has been successfully used for prioritizing candidate genes in recent studies [ 14- 20].
By prioritizing candidate genes, we discovered novel HI phenotypes that were not detected previously in genome-scale screens.
We also showed the capability of our method in prioritizing candidate genes for diseases whose genetic bases are completely unknown.
In the next section, we show that a combined scoring strategy did improve the performance of prioritizing candidate disease genes.
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