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Genes from the genome-wide search were prioritized for study based upon multiple criteria including susceptibility to frequent frameshift mutation, likely antigenicity and likely protein expression in colon cancer.
These results may also provide a means by which biological pathways that mediate the developmental defects of metals are prioritized for study.
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Community-based research can identify mixtures, and their potential emissions sources, to prioritize for study of their additive, cumulative, and synergistic effects [ 88].
One intervention was prioritized for additional study: (17) further study of additional gram-negative perioperative coverage is needed.CONCLUSIONSA modified Delphi technique was used to develop consensus-driven best practices for decreasing wound complications after cTSC surgery.
We prioritized for further study those whose protein product was shown to be selectively expressed in ZG.
If this threshold is not met, no bonus points will be awarded, and the action will remain as ambiguous and be prioritized for further study at the 'jamboree' session.
We have combined phenotypic analysis and whole transcriptome profiling of isoform-specific daf-16 /FoxO mutants to define a subset of 92 DAF-16/FoxO target genes (composed of 57 DAF-16A-specific and 35 redundant target genes; Figure 5, E and F; Table S13) that we have prioritized for further study.
This has implications for follow-up studies, as trait-associated SNPs in conserved regions tend to be prioritized for further studies [ 31] either manually or via algorithms [ 20, 21, 23, 32].
Upon further filtering by potency (cutoff of IC50<10 µM and cluster size greater than 4), a total of 157 representative compounds spanning 17 chemical clusters and 83 singletons were prioritized for further studies.
In this regard the c.1350G > A variant may be prioritized for further studies.
Considering the relationship between in vitro potency and concentration achieved in mice, compounds with a Cmax/TRE of ≥30, AUC0 48/TRE of ≥587, and T>TRE of 100% would likely be efficacious and would be prioritized for further studies.
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