The current in silico model should help accelerate the drug discovery process by using confidence-based stability-driven prioritization, and reduce cost by filtering out the most unstable/undesirable molecules.
Thus, based on these considerations, the algorithm we have devised introduces a topologically-driven prioritization that selects only plausible inclusions of a protein into a FN, as quantified by its PMS, i.e., a score that reflects the ability of a FN to discriminate among the topological patterns of the PPI network, to which the protein belongs.
Taking this approach, we have examined the NR profiling data generated from the pilot phase Tox21 collection of approximately 3,000 environmental chemicals in terms of data reliability, which can be measured by the level of variability/noise, dynamic range, and reproducibility, to assess potential challenges and propose strategies for data-driven assay prioritization.
The global, systematic, objective and multidisciplinary computational analysis presented here allows for the effective, unbiased and data-driven assessment and prioritization of large, biologically compelling gene lists for the purpose of drug discovery.
Clinical bioinformatics should be emphasized for DNB identification and validation to handle data preprocessing and consolidation, the data-driven search, verification, prioritization and biological interpretation of putative metabolic candidate biomarkers, as suggested by Baumgartner et al. [48].
Phenotype-driven strategies for exome prioritization of human Mendelian disease genes.
The package does not only offer an efficient prioritization tool for selecting the most promising drug combinations for further experimental testing, but also produces data-driven hypotheses for their target interactions.
Prioritization is essential.
"Prioritization is a problem," Mr. Sharples said.
It's just a matter of prioritization".
