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Although WES provides sequence information for the great majority of targeted exon sequences, the need for prioritization remains.

Candidate gene prioritization remains an active area of research despite a considerable number of algorithms and applications proposed in recent years (Adie et al., 2006; Britto et al., 2012; Chen et al., 2009, 2011a, b).

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Despite this understanding, implementation and prioritization of generalist education programs remains challenging [ 2].

Thus, in particular where little prior knowledge about the disease and/or gene is available, accurate prioritization of putative disease genes remains a challenge.

Based on the Murcko framework, Schuffenhauer et al. [9] proposed a more complicated and systematical methodology, called Scaffold Tree (ST), to describe the ring systems arranged in a hierarchical tree, which iteratively prunes rings one by one based on a set of prioritization rules until only one ring remains.

The utility of conservation prioritization based on future species ranges remains constrained by our ability to compile and analyse these data for thousands of species over large spatial scales.

105, 106 Since utility depends on context, prioritization of the various diagnostic rules remains an issue of strategic decision making.

Prioritization of candidate genes underlying complex traits remains one of the main challenges in molecular biology [ 11].

Therefore, establishing a national agenda using public health and equity lenses to address the problems most affecting the Panamanian population, such as non-communicable diseases, population aging, and deaths due to accidents and violence, as well as health promotion and disease prevention, remains the objective for the next prioritization exercise.

Prioritization Does the resident appropriately prioritize tasks?

Much remains unknown about the effect of timing and prioritization of vaccination against pandemic (pH1N1) 2009 virus on health outcomes.

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