Overall, we conclude that mathematical models of this type can complement experimenter insight to suggest unexpected regulatory relationships and to guide prioritization of future experiments.
This will facilitate the prioritization of further experiments to confirm hypotheses arising from the position of the motifs, as well as offering insights into how nature arranges epistatic relationships between genes in order to best advance the interests of the cell.
These provide specific hypotheses for the prioritization of phosphatase-kinase targeting experiments.
On preliminary experiments, the prioritization of the test suites of policies P03, P04, P05 took more than 24 hours.
First, standardized and high-quality concentration response profiling, with reproducibility confirmed by comparison with previous experiments, enables prioritization of chemicals based on interindividual variability in cytotoxicity.
The added value of the use of different microarray platforms lies in the prioritization of the pathways for follow-up experiments.
In summary, CNVineta aides in the interpretation of large-scale CNV datasets and prioritization of target regions for follow-up experiments.
Since computation complexity is an important target of the prioritization, the experiment also involves measuring prioritization time of comparison algorithms.
Therefore, the goal of experiment-prioritization is better approached not by assigning functions to genes in a binary fashion, but rather by prioritizing the most promising novel gene-function associations for future small-scale investigations [19], [49], [50].
The computational procedure can therefore be used, for instance, in prioritization of the most promising interactions for follow-up functional analyses or more targeted screening experiments among the exponential number of combinations.
