There were concerns about a lack of connection with employers and a tendency to prioritise academic pathways rather than to provide information about vocational training.
Thus, by improving risk assessment and identifying allele-specific therapeutic responses, further investigation of loci and pathways prioritised in this study could yield actionable results for enhancing perioperative cardioprotection.
Identification of this subset may assist in prioritising human candidate genes and pathways implicated in progression to ovarian cancer.
We hypothesised that a subset of genes involved in normal ovarian epithelial cell functions are also consistently aberrantly expressed in ovarian cancer and identification of this subset would assist in prioritising human candidate genes and pathways implicated in progression to ovarian cancer.
Here, the predefined model prioritise with focus on possible pathways is chosen.
However, the Research Impact Framework presented in this paper is not aligned with any particular philosophy, is not in itself evaluative and does not prioritise impacts or propose causal pathways.
Furthermore, the analysis of pathway mentions could provide valuable hints on pathways that should be prioritised for curation.
Furthermore, variation may result from explicit resource allocation decisions, such as the decision by Wales not to have a Cancer Drugs Fund, prioritising spend earlier in the cancer pathway.
In some cases, supportive care emphasising quality of life rather than aggressive anti-cancer therapy might be recommended, or a pioneering clinical trial utilising Hh-PcG chromatin-silencing pathways blockade should be prioritised in high-risk patients.
This first report of the application of network biology to JIA, integrating genetic association findings and gene expression data, has prioritised protein clusters for functional validation and identified new pathways for targeted pharmacological intervention.
