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Vaccination of individuals prior to the discontinuation of routine vaccination may provide some, possibly considerable, protection against infection [ 11, 23, 24], although it may also result in more mild cases which may be harder to detect.
Scenario c illustrates that vaccination prior to the discontinuation of routine vaccination does play a role in smallpox control by ring vaccination; there were more decontainment scenarios (5/100) when no prior protection exists in the population.
In Figure 3A, we assumed 25% of individuals had protection due to vaccination prior to the discontinuation of routine vaccination; in scenario c of Figure 9, we assumed this fraction was zero.
The model by Halloran et al. [ 11], a stochastic, discrete-time network model omitted the explicit inclusion of response logistics while otherwise used parameter values similar to those in Kaplan et al. [ 9]; the inclusion of residual immunity from individuals vaccinated prior to the discontinuation of routine vaccination, however, led to a more favorable view of ring vaccination.
Similar(56)
Longitudinal and/or cross-sectional studies were included if they reported on the number of patients who discontinued fertility treatment and on patients' stated reasons for discontinuation or predictors of discontinuation (assessed prior to the occurrence of discontinuation behaviour).
Add-on was defined as the addition of a new PAH medication other than the index medication at least 60 days prior to the date of discontinuation or 60 days prior to the end of the study period if there was no evidence of discontinuation.
The calcium level recorded 14 days prior to the date of the laboratory value most proximal to discontinuation was used to predict reinitiation.
Among all patients who completed treatment prior to discontinuation of the 150 mg arm (81 84 patients per group), there was a distinct reduction in the flare rate and an increase in the time to flare for patients in the 150 mg arm compared with that seen in either the placebo or the 75 mg arm.
The primary outcome was premature discontinuation of AIs, defined as stopping the medication prior to the end of prescribed therapy.
This has been previously documented in epidemiological studies conducted in healthcare settings, supporting the need for multiple cultures prior to discontinuation of contact precautions or, alternatively, the advisability to label as continuously colonized a patient following the first isolation [ 17].
The few secondary bacterial infections occurred prior to discontinuation of IVAMT, and no patients required readmission because of suspected or proven infection.
Related(12)
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