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The method needs no prior, time-consuming alignment of the proteins and therefore an on-the-fly searching of PDB scale crystal structure database for potential bioisosteric replacements is feasible.
The advantage of such a preliminary screen is that recombinant proteins containing guanylate cyclase activity are identified prior to time consuming full characterization studies as outlined in Figure 7.
These methods are technically demanding, require construction of genomic libraries prior to hybridization, are time consuming and do not scale well with the number of samples.
Once suitable reservoirs are identified in an initial screening for further evaluation, CO2-Prophet screening model can be used for a better understanding of proposed EOR project performance and site specific incidental CO2 storage potential prior to launching detailed and time consuming reservoir simulation studies.
Prior to Pepper, draftsmanship was a "time consuming" and "frustrating rather than enlightening" business.
The clinical significance of splice isoforms remains to be elucidated, mainly because their detection has until recently required time consuming cloning steps prior to sequencing.
Completion of diaries is a time consuming occupation, may alter behaviour, and require prior user training.
Nevertheless, this will be necessarily a time consuming and costly process and requires reasonable prior hypotheses to be generated.
Prior approaches in development of Short Tandem Repeats (STR) markers were time consuming and inefficient.
Prior to the availability of personal measurement devices, measurement of RF-EMF was complex and time consuming.
Prior to this, primary human cells were resilient to conventional homologous recombination making gene targeting extremely inefficient and time consuming.
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