For clfA, this is the first time such a program has been used in profiling the SD repeats, hence no prior termination sequence has previously been reported.
Response evaluation was performed after two to four cycles ("mid term" staging) and after completion of therapy, i.e. after 6 cycles as scheduled in the protocol or prior termination in case of progressive disease (PD) or intolerable toxicity.
Although the association found between depression and prior termination is not statistically significant, its size and near significance might lead one to see it as evidence that choosing pregnancy termination over childbirth increases the risk of depression in younger women.
Binary logistic regression adjusted for potential confounding factors included prior termination, placenta previa, IVF, fertility treatment other than IVF, smoking, maternal age (in the categories under 35 and 35 and over), maternal diabetes (including both pre-pregnancy and gestational diabetes) and BMI >25 before pregnancy.
The groups were different in terms of prior terminations, pre-pregnancy obesity (BMI >25), IVF and other fertility treatments, smoking, chronic hypertension and maternal diabetes.
Similar to other studies, the women of AMA in this sample experienced more prior terminations and IVF and other fertility treatments [ 18- 20].
Increased prevalence of postpartum depression was also associated with an advanced maternal age (≥40), anaemia, prior terminations, gestational diabetes, a major congenital anomaly and admission to neonatal intensive care unit.
Furthermore, women experiencing postpartum depression were more likely to have reproductive risk factors, such as prior terminations, anaemia, amniocentesis, gestational diabetes, maternal diabetes mellitus and fear of childbirth compared with women without postpartum depression (table 1).
Possible confounders (maternal age, birth weight, foetal sex, smoking status, marital status, SES, induction, preeclampsia, gestational diabetes, maternal diabetes mellitus, fear of childbirth, placental abruption, placenta previa, IVF, prior terminations, prior miscarriages, prior CS and time period) were selected based on bi-variable analyses (p < 0.1).
An increased prevalence of postpartum depression among women without a history of depression was associated with nulliparity, smoking during pregnancy, caesarean birth, prior terminations, fear of childbirth, a major congenital anomaly and preterm birth compared with the reference group with no postpartum depression.
They had more prior terminations (<0.001), were more likely to have a body mass index (BMI) >25 (<0.001), had more in vitro fertilization (IVF) (<0.001) and other fertility treatments (<0.001) and a higher incidence of maternal diabetes (<0.001) and chronic hypertension (<0.001).
