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Thirdly, prior sensitisation by non-tuberculosis mycobacteria, which is common in high TB prevalence countries, could lead to false positive TST results in some patients.
Similarly, taxane-induced hypersensitivity can occur without prior sensitisation in more than half of cases [ 9], suggesting that both drugs may act via similar immune-mediated mechanisms.
These lymphocytes are potent anti-tumour effector cells both through an ability to directly kill target cells without the need for prior sensitisation, and also secrete cytokines that influence the adaptive immune response [ 17].
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Prior to sensitisation, the TiO2 photo-anodes were pre-heated at 150 °C for 30 min, allowed to cool.
Reduced expression of these HLA allotypes leaves the infected host cell vulnerable to lysis by NK cells which, unlike CD8+ CTLs, are primed to kill virally infected cells without requiring prior antigenic sensitisation 18.
18 However, pre-existing atopy or associated characteristics may also influence subsequent infection risk, as rhinovirus bronchiolitis has been found to occur more frequently in infants who had prior allergic sensitisation.
Prior to sensitisation assays the toxicity of niacinamide was determined and the optimal concentration selected as a low and clinically relevant dosage without a significant effect on cell survival.
In the absence of valid biomarkers of causal relationship to the exacerbation, the alleged trigger (allergic or other) based on the parental report, physician perception, prior documented sensitisation (skin tests or specific IgE), pollen, particles, ozone (and other) levels in the child's living area will serve to infer a trigger.
Prior to the survey, sensitisation visits were conducted in each village.
One possible explanation is that sensitisation occurred prior to the provision of the intervention - equally in both groups.
Starting from one day prior to collagen II sensitisation, one group of mice was treated with 10 mg/kg (100 μL subcutaneously once per week) of a monoclonal antibody directed against sclerostin [ 18- 22] and the other with PBS (100 μL subcutaneously once a week).
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