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This study was an opportunistic study arising from access to the pandemic influenza surveillance database and we did not perform prior sample size calculations.
As this was a phase II trial we did not estimate a prior sample size.
No prior sample size determination was made due to the observational character of the present study.
Considering that α is the prior number of pressure ulcers and α+ β the prior sample size, again we can see that as y ¯ increases the prior PrU rate goes up and as s2 decreases the prior sample size increases.
However, a prior sample size calculations was reported in only one studies, increasing the risk of false negative outcomes.
A Beta prior is equivalent to specifying a prior mean of α π / based on a prior sample size of α π + β π.
Similar(48)
With 300 samples, there will be considerable sample size/power to detect differences in bacterial composition and diversity at infants 1 year of age based on exposure group, compared to prior sample sizes of microbiome studies [ 36- 39].
Inclusion criteria included: national studies or those reporting large scale population-level data; data published from 2000 to 2010 and trend data prior; sample sizes over n = 1000, or fewer subjects in small nations.
Between-study variables included information on study characteristics (author(s), publication year, journal, study design, follow-up duration) and sample characteristics (country, stage of lymphoma, International Prognostic Index [IPI], incidence of transformed lymphoma, number of prior treatments, use of rituximab in prior therapy, sample size).
Finally, a total of 1434 (32.2%) was successfully recruited, hence achieving the prior calculated sample size and the expected response rate.
The well-defined sampling design and prior estimation of sample size reduces sampling errors.
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