Sentence examples for prior pathway from inspiring English sources

Unlike Chuang et al [18], who use prior pathway knowledge to examine the plausibility of a pathway's involvement, all assessment of biological interpretation in our methods is retrospective; we first construct a network, then examine its structure to identify highly-connected sub-graphs and take these groups of genes to look for common biological roles.

It also introduces the pre-processing PERA step, which improves the inclusion of prior pathway knowledge by making it more systematic.

It was found that the use of log counts when normalized for sequence depth is a good strategy for data transformation prior pathway analysis.

In this study, we also incorporate prior pathway information from signaling databases to narrow the parameter search space and improve the accuracy of the models.

The method of calculating the score is presented in algorithm 1. Step 4: If the score is significantly lower than the maximum possible score (L(L+1)/2) and the number of inconsistencies is higher, return to Step 1 to change the regulators that were undetermined from the prior pathway knowledge.

Both the activation barriers and kinetic results demonstrate that Path A is the prior reaction pathway.

Being a computational approach based on the prior knowledge, pathway enrichment analysis is widely used in the study of genotype-phenotype associations [ 1].

On the other hand, a potential disadvantage is that it doesn't use all the information content in the model signature and thus does not evaluate the consistency of the model signature in the different context prior to pathway estimation.

To improve specificity, we used a network approach, whereby genes with similar characteristics may be grouped prior to pathway analysis.>> A weighted gene co-expression network was constructed as outlined in Methods.

Our results highlight the need to apply powerful gene score methods prior to pathway enrichment tests, and that controlling for genes that attain genome wide significance enable further biological insight.

The algorithm given below enables one to detect bootstraps prior enumerating pathways running the FindPath algorithm.