All cell lines were obtained from the ATCC and passaged minimally prior to completing these experiments.
Accordingly, we specified minimally informative prior distributions corresponding to a Normal (0,10) prior distribution for the pooled mean effects relative to usual care, d Ak ) and the study-specific baseline effects, μ ib and a Uniform (0,2) prior distribution for the between-study standard deviation on the log odds ratio scale σ[ 34].
9 13 14 Analyses were done using Markov chain Monte Carlo methods with minimally informative prior distributions.
This resulted in the isolation of Clostridium difficile DJOcd1 and E. coli DJOec1, which were minimally cultured prior to undergoing fecal competitive experiments with the B. longum strains.
We used an extension of multivariable Bayesian hierarchical random effects models for mixed multiple treatment comparisons with minimally informative prior distributions.
Multi-arm studies are included in model 3 based on equations (8) and (9) in the same way as in model 2. To complete model 3, the parameters α k, γ m and τ are given minimally informative prior distributions.
The stochastic parameters (β(s) are given proper but minimally informative prior distributions, while the logical expression for precision (σ(s)) allows the standard deviation of the random effect distribution to be estimated.
17, 18 Sitagliptin is minimally metabolized prior to excretion and does not appear to inhibit or induce cytochrome P450 enzymes, making the potential for adverse interactions with other medications low.
The posterior median and 95% credible intervals of intervention effects relative to usual care were unaffected by placing alternative minimally informative prior distributions on τ (Additional file 1: Appendix 2).
We used minimally informative prior distributions for log rate ratios (−10, 10) and for random effects standard deviations (0, 2), so the findings should be close to those obtained with frequentist methods.
