Sentence examples for prior differentiation from inspiring English sources

We did not succeed to show the concomitant presence of Runx1 and MyoD on MyoD target genes, given that it has previously been demonstrated that in proliferating conditions, only a small fraction of MyoD contributes to the repressive remodeling of its target genes, prior differentiation.

Therefore successful treatment of stroke requires prior differentiation between ischemic and hemorrhagic damage.

First, the expression of E-cadherin and N-cadherin was determined in wildtype, 9J (E-cadherin null), N19 (N-cadherin heterozygous), and N95 (N-cadherin null) ES cells, with or without prior differentiation by retinoic acid treatment (Fig. 1A).

These results suggest that H3mm7 is expressed prior to differentiation and supports the differentiation process.

Furthermore, BrdU and Tunel experiments showed that the results were not a reflection of increased neuroblast proliferation prior to differentiation or differential apoptosis respectively as there were no differences between any of the experimental groups.

We further evaluated the function of H3mm7 in isogenic C2C12 cells, which express H3mm7 prior to differentiation stimuli and are used as a differentiation model of myogenesis24.

Primary myoblasts were transfected 6 h prior to differentiation, to allow protein silencing or overexpression effective after differentiation (see scheme in Supplementary Fig S1).

MyoD is expressed in actively proliferating cells prior to differentiation, followed by increased myogenin expression at the beginning of differentiation [ 4- 6].

To gain global insights into gene expression alterations upon ZEB1 KD, we performed replicate RNA-seq experiments in control and ZEB1 KD cells prior to differentiation (day 0) and 2 days after the onset of differentiation ('Materials and methods').

Thus, if there is a severe genetic mutation causing rapid aging such as in Progeria, this will need to be corrected prior to differentiation; otherwise, the disease will simply be played out again in the dish following differentiation.

For the experiments done with NG108 cells differentiated into neuronal-like cells, cells were transfected 24 h prior to differentiation.