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We did this for several different models that use previously proposed interaction priors as well as the prior derived from causal inference.
Therefore, a strong gene-specific prior derived from the Narsai et al. estimates could not be justified.
The normal mixture approach with a prior derived from air quality predictions obtained in M3 (M5) yielded the second best predictions.
The second best method in terms of correlation with AGS (0.74) and MSE (0.09) was the Bayesian method that uses normal mixture prior derived from predictions of the 2001 mixed effects applied in the 2002 context.
An increase in accuracy of 1-2% for all traits was observed in the Australian Holstein population when using a prior derived from the Nordic Holstein population compared to using no prior information.
Results showed an increase in accuracy of up to 3.5% for the Jersey population when using BayesRS with a prior derived from Australian Holstein compared to a model without location specific priors.
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The Bayesian framework underlying the approach potentially allows application to any amount of data by using informative priors derived from previous translocations or expert opinion.
The pooled effect sizes of RCTs were changed by using different power transform priors derived from observational evidence.
This is similar to the weighting of the empirical priors derived from observational evidence discussed in the background section [ 15, 21].
A hyperprior approach with mean-values of the exponential priors derived from a uniform distribution between 0 to 10 was determined to fit best the data.
In the work presented here, we perform 100 bootstrap operations for each of four cases: gene expression data alone (with no priors), or using priors derived from the literature, from PPI data, or from a combination of the two.
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