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The main reason is that we introduced block grouping operation in the prior data generation procedure.
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Samples from individuals were coded at the time of collection and then pooled prior to data generation, removing any possible association of analytical measurements with a single donor.
Without the benefit of extensive previous RNA-Seq studies, it is difficult in most cases to estimate prior to data generation the optimal sequencing depth or amount of sequencing data required to adequately power the detection of DE in the transcriptome of interest.
In this framework journals agree to accept a future publication based on acceptance of pre-registered proposals and prior to any data generation.
The organizing laboratory (Department of Forensic Molecular Biology, Erasmus MC University Medical Centre Rotterdam) provided genotyping protocols, allelic ladders, and tools for allele calling to all participating laboratories, and organized a quality control exercise prior to population data generation (for details see below).
Furthermore, when sample size is moderate and the statistical prior does not correspond to the data generation prior, we have no clear information on how close <img src="http://journals.plos.org/plosone/article/asset?id=info?doi/10.1371/journal.pone.0014770.e150.PNG" class= inline-graphic"/> is to being uniform.
The utilization of the singular spectrum dictionary allows for the incorporation of prior knowledge regarding the data generation process which can significantly improve the reconstruction performance [25].
It is worth noting that during training of the proposed data-driven model we did not take into account any prior knowledge about the data generation process.
The current results compare favorably with prior data obtained with previous generations, including 64-slice CTA.
Emulation of DCP data generation is justified by the need of debugging a DAS prior to system delivery to final usage and by the difficulty of testing the real system.
Data generation, transcription, and analysis were carried out by experts with prior experience of handling qualitative data.
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CEO of Professional Science Editing for Scientists @ prosciediting.com