Sentence examples for prion of a from inspiring English sources
Classical scrapie (subsequently referred to as scrapie) and Bovine Spongiform Encephalopathy (BSE) are transmissible spongiform encephalopathies (TSEs), a group of fatal neurodegenerative disorders of animals and man which are characterised by the deposition of a misfolded isoform (PrPSc or prion) of a cellular protein (PrPC), spongiosis and gliosis.
[URE3] is a prion of Ure2p, a regulator of nitrogen catabolism, while [PSI +] is a prion of Sup35p, a subunit of the translation termination factor Sup35p.
Aside from the degree to which sequence specificity might determine differences in how chaperones interact with different prion proteins, the structural conformation of prion aggregates formed by them could contribute to determining which chaperone functions are more important for prion propagation of a particular prion.
The amyloid model used in this study is the prion domain of a fungal prion protein: HET-s [9].
In turn, if A1 and A4 have structurally similar prions, then we expect the prion phenotypes of a wild-type strain induced by the corresponding cell extracts to be similar [53], [54].
The continued propagation of the prion state of a protein in growing yeast cells requires the ability to generate and transmit molecular seeds – propagons - to new daughter cells.
Specifically, the prion form of a protein known as PrP is the causative agent of the TSEs, which afflicts humans and other mammals.
Ure2 is the protein determinant of the epigenetic factor [URE3] of Saccharomyces cerevisiae, which has been demonstrated to represent a prion of yeast [14], [15].
The beneficial [Het-s] prion of Podospora anserina poses an important contrast in its structure, biology, and evolution to the yeast prions characterized thus far.
The decrease in MMP-9 activity caused by pathogenic prions limits the degradation of A-beta.
Previous work by the Prusiner team and others had shown that prions consist of a cellular protein that has misfolded into an abnormal form.
