Sentence examples for prion for from inspiring English sources
In 1974 an American neurologist and neuroscientist, Stanley Prusiner, entered the field and coined the term prion (for proteinaceous infectious particle, and incorporating the first two letters of his surname).
No one knows what makes a normal protein become a prion, for example, or how to prevent the transformation.
Under our experimental conditions, two of four cell lineages (L1E and L3E) maintained the prion for the duration of the experiment (that is, ∼100 generations), one lineage (L4E) maintained the prion for ∼80 generations, and one lineage (L2E) maintained the prion for ∼60 generations.
Yuan et al. now reveal that the bacterium Escherichia coli can propagate a yeast prion for over a hundred generations, even when the cells can no longer make the protein that serves as the trigger for the initial conversion.
As only two of four lineages retained the prion for the full duration of our experiments, propagation of the Sup35 NM prion may be less stable in E. coli than in S. cerevisiae (DiSalvo et al., 2011).
Infectious prions are produced when normal prions, for unknown reasons, assume a flattened shape that prevents them from being broken down by the body.
In our hands, the adequate amplification of soil-bound prions for the Elispot assay required less than 4 weeks.
The variance of the score distribution of candidate prions for which there is strong experimental evidence [ 38], reflects the high sequential variability that aggregation-prone domains can accommodate.
Given the need for predictive tools that can forecast protein prionogenicity at a genomic scale to guide experimentalists, and also to provide a global view of the relevance of prions for the regulation of cellular processes, we decided to build PrionScan, as an open source of up-to-date prion predictions for all the proteins annotated in public databases.
Expression of PrPC in the host organism is necessary for prion replication and for prion neurotoxicity.
In addition, we confirm in the mouse the importance of CPEB3's prion formation for CPEB3 function.
