Sentence examples for prion characteristics from inspiring English sources

Similarly, when cell extracts prepared from weak or strong [PSI+] variants are introduced into [psi−] cells, the resulting [PSI+] cells retain the original prion characteristics [53], [54].

If the strong and weak [PSI+] of the A1 and A4 strains correspond to structurally different prions, then we expect these prion characteristics to be transmitted to a wild-type strain [53], [54].

In view of the similarities between the L-type and BSE/JP24 prion characteristics (9 ), this discrepancy may result from differences in the methods used for PrPres detection.

CJD was confirmed in the third patient, who had clinicopathologic, codon 129, and prion characteristics similar to the most common sporadic CJD subtype (MM1/MV1) (35).

By making use of well-characterized genetic assays determining prion-like characteristics of glutamine-rich domains in different proteins, we have identified the Q domains of both the GAF isoforms as prion-like domains.

The characteristic prion domains may vary between species e.g., characteristic fungal prion domains are not found in mammalian prions.

We describe the clinical, histopathological and pathological prion protein (PrPSc) characteristics of a Dutch family with a novel 7-octapeptide repeat insertion (7-OPRI) in PRNP, the gene encoding the prion protein (PrP).

In this report, we describe the clinical, histopathological and pathological prion protein (PrPSc) characteristics of two Dutch patients carrying novel adjacent stop codon mutations in the C-terminal part of PRNP, resulting in either case in hereditary prion protein amyloidoses, but with strikingly different clinicopathological phenotypes.

Based on these compositional characteristics, prion-like sequences have been underscored at a genome scale in yeast [ 24].

These observations might indicate that an overactivity of SOD1 caused by or coinciding with a disturbance of a PrP regulatory function could be responsible for characteristic prion pathology and cellular demise.

51, 52 These models can have single or multiple copies of the gene and are extremely useful for strain typing new unknown and uncharacterized natural isolates and for characterizing strain-specific characteristics of prion diseases as well as the various prion strains capacity or potential ability to cross species barriers.