This proof of principle study has shown that microarray as a single platform assay can achieve reasonable diagnostic accuracy with the ability to differentiate lymphoma from non-cancerous reactive lymphadenopathy, and also classify three common subtypes of lymphoma.
This proof of principle study has shown that the sensitivity of the automated immunofluorometric Mcm5 test on bile aspirates for detecting pancreaticobiliary malignancy was superior (four times more at the 1000 cells per well cut point) to that of brush cytology, while maintaining a high specificity.
Here, first principles studies have performed on the electronic and transport properties of borophane with defects.
Proof-of-principle studies have demonstrated the induction of neural precursor cells, neurons, cardiomyocytes, and insulin-producing β islet cells.
Recent proof-of-principle studies have shown that ZFNs can also be used to create targeted NHEJ-mediated knockout mutations in endogenous zebrafish genes.
Such nanoparticles are non-inflammatory, non-immunogenic [7], [14], [16], and our own proof-of-principle studies have demonstrated that they are non-toxic in the eye [13].
Proof-of-principle studies have demonstrated rapamycin-induced clearance of CF-associated pathogens and concomitant decreased pathogen-induced lung inflammation.
Proof-of-principle studies have shown that gene expression (GE) also is a heritable human variation that exhibits differential intensity distributions among ethnic groups.
These proof-of-principle studies have suggested a number of strategies to modify the fly genome, differing mostly in the way the Cas9 and gRNA are delivered.
In the past years, a number of proof of principle studies have validated the feasibility of epigenetic editing in reporter plasmids, viral DNA, and endogenous targets (reviewed in [ 18]) and paved the way towards more comprehensive studies.
