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As the dynamics of (even simple) regulatory networks are hardly predictable based on biological intuition alone, a systems biological analysis, i.e. the application of mathematical modelling techniques, appears to be an appropriate strategy to address the principles of regulatory interactions in pluripotent cells.
This observation gives insight into the design principles of regulatory regions in both phyla.
Our framework for comparative functional genomics is applicable to any complex phylogeny, and can help test these principles of regulatory evolution in other responses and species.
These results transfer to synthetic biology, where design principles of regulatory circuits must accommodate the neutral evolutionary forces that will wreak havoc on 'industrial' (wild) populations.
We and others are exploiting ChIP-Seq and RNA-Seq to understand the evolutionary principles of regulatory divergence across transcription factors (TFs) and non-coding RNAs.
Emerging principles of regulatory evolution strongly favor genetic diversity in cis-regulatory DNA and not trans-regulation of gene expression to explain interspecies differences in gene expression.
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"The principle of regulatory cooperation aims to harmonize standards between the US and Europe, and gives a fairly big platform for large multinational companies and their lobbies.
By conducting a comparative analysis with a kinetic model of the Calvin-Benson cycle and a model of plant carbohydrate metabolism, we demonstrate that the principle of regulatory on/off minimization coupled with dynamic FBA can accurately predict the changes in metabolic states.
The bilaterians share principles of developmental regulatory design that are uncannily similar in the most diverse species, such as flies.
By constructing simple gene circuits, such studies have generated new insights into the design principles of gene regulatory networks.
However, the evolutionary dynamics of these networks across organisms, which would reveal important principles of adaptive regulatory changes, are poorly understood.
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