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The group then returned to the principles of GRADE to determine how an overall ranking might be addressed.
This approach is encouraged by BMJ and the Cochrane Collaboration [ 20] which have adopted the principles of GRADE for the evaluation of evidence in systematic reviews [ 21].
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The second intervention was based on the principles of Graded Activity as developed by Lindström et al [ 21, 22] and adjusted to the Dutch situation.
Overall quality of evidence was assessed based on study quality, results from sensitivity analysis, and principles of the grades of recommendation, assessment, development, and evaluation (GRADE).
The authors were advised to follow the principles of the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system to guide assessment of quality of evidence from high (A) to very low (D) and to determine the strength of recommendations as strong (1) or weak (2).
Three summative formal essays were used as a principle means of grading the teacher-participants in the course.
The intervention incorporates core principles of the behaviour graded activity theory (BGA).
The intensive group training protocol combines exercise therapy with principles of behavioural therapy ("graded activity") and back school.
The initial phase I and II studies showed that myelosuppression was the principle drug-related toxicity, with a frequency of grade 3/4 neutropenia of 50% and grade 3/4 thrombocytopenia of 15% (Hanauske et al, 2001).
During that time, the test -- the Praxis Principles of Learning and Teaching for Grades 7 to 12, called the Praxis P.L.T. 7-12 -- was given eight times, to a total of about 40,000 people.
People with severe CFS/ME should be offered an individually tailored activity management programme as the core therapeutic strategy, which may be delivered at home, or using telephone or email if appropriate, drawing on the principles of cognitive behavioural therapy (CBT) and graded exercise therapy (GET).
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