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We discuss general principles of combinatorial materials screening, followed by the discussion of the opportunities facilitated by combinatorial technologies for discovery and optimization of new sensing materials.
This chapter presents the basic concepts and principles of combinatorial topology of polyhedra; these are used to develop the boundary representation algorithm.
In this article, we introduce a screening strategy that takes advantage of both the robustness of protein NMR spectroscopy as the detection method, and the basic principles of combinatorial chemistry to enable the screening of large libraries of fragments (>105 compounds) preassembled on a common backbone.
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The principle of combinatorial control of gene expression that is addressed in this paper sheds light on the mechanisms used by the biological systems to achieve tight regulation of the entire process.
Owing to their diversity, target affinity, and specificity, natural products have demonstrated enormous potential as modulators of biomolecular function, been an essential source for drug discovery, and provided design principles for combinatorial library development.
These libraries also facilitate the implementation of combinatorial pathway engineering principles and the engineering of more efficient microbial cell factory for various biomanufacturing applications.
Therefore, this finding is the best proof of principle that a combinatorial method of deletion of barriers and activation of enhancers can progress pluripotent reprogramming with high efficiencies and with accelerated kinetics (Table 1).
The principle of an OBOC combinatorial library is the synthesis of many compounds in solid-phase by a "Mix-Split" approach [9].
Unifying principles and cross connections, however, have begun to appear in various areas of combinatorial theory.
Examples from a wide variety of sensors based on various energy-transduction principles that involve radiant, mechanical, and electrical types of energy demonstrate the impact of combinatorial methodologies across diverse kinds of sensing materials.
Insight into the corresponding molecular mechanisms is developing rapidly and enables adaptation of the emerging principles to the creation of artificial binding proteins in vitro, using the techniques of combinatorial biotechnology.
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