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The availability of novel noncytotoxic pharmaceutical and natural products in clinical development create opportunities for improving the therapeutic index through the principles of combination therapy.
A new series of hybrids of lamellarin D and combretastatin A 4, 1,2-diphenyl-5,6-dihydropyrrolo [2,1-a] isoquinolines, were designed as cytotoxic agents based on principles of combination in medicinal chemistry and taking the parent compounds' different anti-proliferative mechanisms into consideration.
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On the basis of the principle of combination of active structural moieties, a modified and efficient synthetic method for three series of novel indole-based 1,3,4-oxadiazoles is described.
Richter, the French chemist Joseph-Louis Proust, and the English chemist John Dalton, despite their theoretical insights, had contributed little empirical evidence toward elucidating the principles of chemical combination.
For further general discussion of principles of modal combination, and the prospects for brute necessary connections, see Bricker 1991, Nolan 1996, Wilson 2010, and Weatherson (forthcoming).
Most chemists would think this implausible because one of the most basic principles of chemical combination is the fact that argon almost never forms bonds (see Bader, 2009 for a response).
His paper Experiments on Colour laid out the principles of colour combination and was presented to the Royal Society of Edinburgh in March 1855.
Although the processes of generation of the two gene sets are different (Glean for annotVer 1.0 [ 16]), they are comparable, because the principles of evidence combination are nearly the same.
A nonlinear separation principle for combination of a nonlinear full state feedback controller with a state observer in cascade is also presented.
The article demonstrates the practicability of strategic management of water resources based on the principle of a combination of river basin management approaches and the consideration of regional development strategies.
Proof of principle of this combination treatment approach in vivo has also been shown in HD fly models (Sarkar et al., 2008).
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contents of combination
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com