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Based on kinetic principles imposed by fluctuation of protein concentrations in the cell and the different affinities of these proteins to cooperatively bind to DNA, a simplified model (Fig. 7) could explain the TR and GATA2 state in the TSHβ gene down-regulation by thyroid hormone.
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(4) One can hold that perfectionism inclines toward inequality, but that other non-perfectionist principles impose an egalitarian constraint on the pursuit of perfectionist values.
It has long been recognized that fundamental physical principles impose a limitation on the specificity of biomolecule interactions 19, 20.
Nonetheless, whatever the size of the problem, ethical principles impose the inclusion in any cancer control programme of actions to prevent occupational exposure and environmental contamination with carcinogens.
So we conclude that the principle imposing b1 on me cannot be reasonably rejected.
I cannot reject the racist principle simply because of the burden it imposes on me after all, the random principle imposes an identical burden on someone else.
An uncertainty principle imposes a fundamental limit on the ability to extract detailed information about two distinct attributes within a short period of time.
If a principle imposes a certain burden (b1) on me, but every alternative imposes a greater burden (b2) on someone else, then b1 does not give me a reason to reject the principle.
Seyla Benhabib thus complains that "public reason in Rawls's theory is best viewed not as a process of reasoning among citizens, but more as a regulative principle, imposing certain standards upon how individuals, institutions, and agencies ought to reason about public matters.
According to Cervelló-Royo et al. (2015, p. 5963), this principle imposes an important challenge for individual investors and companies, because forecasts of future prices are subject to occasional unexpected fluctuations that do not depend on the historical behavior of the markets.
These results revealed that the cortical actin network, in principle, imposes a critical physical barrier for HIV-1 entry, which is however not apparent in the context of infection with X4-tropic HIV-1 due to the triggering of cofilin-activating signals.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com