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2. Adopt individualized criteria to choose adequate drugs for every clinical condition according to the RUM principles (efficacy, safety, convenience and cost).
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In principle, efficacy of biomaterial development for the cell cultures can be improved by using high-throughput techniques that allow screening of a large number of materials and manipulate microenvironments in a controlled manner.
The principle efficacy variable (primary endpoint) will be calculated for each of the affected areas, as an indicator variable: (1. There is a lesion in the area/0. No lesion in the area) at 60 days from baseline.
The principles of efficacy and cost-effectiveness in genetic testing are not fully accepted among residents.
Less than half appeared to comply with principles of efficacy (attitude number 2, 48.3%) and cost-effectiveness (attitude number 3, 46.3%) in this field (Table 4).
Furthermore, the majority of residents do not recognize the importance of the principles of efficacy and cost-effectiveness in genetic testing.
Although the vast majority of participants recognized the important role of genetic tests in prevention, as well as the need for evidence-based guidelines, complex prevention strategies, and genetic counseling, the principles of efficacy and cost-effectiveness appear to be not so widely accepted.
For example, the percentage of public health professionals who agree that the selection of predictive genetic testing to be delivered to the population should be based on the principles of efficacy and cost-effectiveness are higher than those found among Italian physicians in another survey [ 44].
In principle, the efficacy of drug therapy can be followed by monitoring the decline in fragment abundance.
Paradigm includes a model in which cancer vaccines are investigated in two types of clinical trials: proof-of-principle and efficacy.
A clinical development model has suggested that cancer vaccines be investigated in 2 categories of clinical trials: proof-of- principle and efficacy.
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