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Model-based methods have many appealing qualities: the assumptions made are transparently stated and, most importantly, the generative perspective enables principled predictions of expression levels under perturbations.
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Using accurate binding specificity measurements together with principled TF binding prediction methods can provide a competitive alternative to traditional condition specific ChIP-chip experiments, especially when TF binding prediction incorporates multiple additional data sources.
Results on our carefully constructed test set demonstrate that principled data fusion can significantly improve the performance of binding prediction methods.
Results on a carefully constructed test set from the mouse genome demonstrate that principled data fusion can significantly improve the performance of TF binding prediction methods.
They are principled.
Strong, detailed, clear, principled.
Note the "principled" part.
This is not principled.
"How principled of you".
Gosh, so brave, so principled.
The resignation looks admirably principled.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com