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In one of its many uses in drug discovery, SACP provides an efficient, thermodynamically principled method of ranking chemotype replacements for scaffold hopping and manipulating physicochemical characteristics for drug development.
This paper proposes a principled method for evaluating design choices and choosing parameter values.
We subsequently demonstrate that such an arrangement can provide a principled method for the top-down control of attention during action perception, resulting in significant performance gains.
Entitled "Appendix B: The Doctrine of Types," the appendix represents Russell's first attempt at providing a principled method for avoiding what soon was to become known as "Russell's paradox".
In summary, our results suggest that Thompson sampling might not merely be a useful heuristic, but a principled method to address problems of adaptive sequential decision-making and causal inference.
An important contribution of this paper is a principled method for optimizing the design of the color targets and the color target detection algorithm based on training data, instead of relying on heuristic choices as in our previous work.
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More statistically principled methods for handling missing data also exist.
As a result, there is a persistent need for practical, principled methods to infer the modular organization of genes from genome-scale data.
As principled methods (e.g. multiple imputation) take into account the special characteristics of cost data that affect their analysis, a principled method for dealing with missing data will be applied to our economic evaluation [ 93].
By contrast, the former principled methods are likely to be consistent under MCAR and sometimes MAR mechanisms.
Therefore, it is still of great interest to develop principled methods for identifying chromatin states within and across multiple genomes.
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