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A second reason is that we lack a principled, integrated system that allows us to perform a joint evolutionary inference of homologous recombination, along with inference of the substitution process and patterns of genomic gain and loss (nonhomologous recombination).
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On the basis of the CAFA experiment, it seems that the most powerful methods will be those that will devise principled ways to integrate a variety of experimental evidence and weigh different data appropriately and separately for each functional term.
Liu (2002)'s proposal of internally vs. externally caused emotions may provide a principled account to integrate the distinction between inchoative vs. homogeneous state in Tsai et al. 蔡美智等 (1999) and the division of type A vs. type B verbs in Chang et al. (2000).
The kernel fusion and transformation step in spectral clustering (see equations 3, 4, and 5) provided a principled way of integrating information in that the sum of two kernel functions does not require exceptions and heuristics.
Furthermore, we show how orosensory information can be integrated with internal signals in a principled way, resulting in accounting for experimental results on consummatory behaviors, as well as the pathological condition of over-eating induced by hyperpalatability.
Ethical- Demonstrates honesty, integrity and respect, and makes principled decisions.
A hierarchical knowledge structure was characterised as "a coherent, explicit and systematically principled structure, hierarchically organised" which "attempts to create very general propositions and theories, which integrate knowledge at lower levels, and in this way shows underlying uniformities across an expanding range of apparently different phenomena" (1999a: 162, 162).
But just as important, the Remedial Right Only Theory, when integrated into a comprehensive theory of self-determination that includes a principled account of when intrastate autonomy arrangements warrant international support, will address the concerns of national minorities in cases in which they do not have a unilateral right to secede.
These considerations motivated us to investigate and compare different principled machine learning approaches in order to improve the sensitivity and specificity of detecting ERα/SRC-1 DNA binding sites by integrating multiple types of information.
They are principled.
Strong, detailed, clear, principled.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com