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A forward numerical model of the TOF P-UPS is coupled to an inversion algorithm, based on the genetic optimization principle, targeting the determination of the orthotropic elastic parameters, and the quality of the inversion is demonstrated for synthetic data representative for composites.
As a proof of principle, targeting the globally deregulated DNA methylation has shown effective anti-cancer potential; namely, 5-azacytidine and 5-aza-2-deoxy-cytidine, both inhibitors of DNA methyltransferases, are clinically approved epigenetic drugs for treating high-risk myelodisplastic syndrome, counteracting DNA hypermethylation in cancer cells [ 6].
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First, he might invoke the volenti principle and insist that the harm principle targets only non-consensual harms.
And the third piece of theory is a moral principle targeted to promises directly, what Rawls call the Principle of Fidelity.
These different biochemical pathways can be, in principle, targeted pharmacologically, by prodrugs, for instance.
In principle, targeted HaploSeq is blind to genotyping and can be used to identify genetic variants de novo within the targeted loci.
In principle, targeted enrichment in conjunction with NGS provides emerging possibilities in many areas relying on molecular-based technologies ranging from microbial testing to diagnostics [ 50].
In principle, targeted inhibition of the CRL4A ubiquitin ligase complex may reduce skin damage and slow down the aging effect caused by chronic exposure to harmful UV rays.
Similar platforms based on the same principles, targeting the HLA genetic diversity in other global populations (e.g., Southeast Asia), are currently being designed to support large cohort-based studies.
[T]he expensive first edition of the Principles targeted the conservative leisured classes: Lyell sought to reassure them that geology presented no threat to Christianity and offered no support for atheistic radicalism.
The first edition of Principles was expensive, and hence targeted as an audience what Lyell considered his most important demographic: [T]he expensive first edition of the Principles targeted the conservative leisured classes: Lyell sought to reassure them that geology presented no threat to Christianity and offered no support for atheistic radicalism.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com