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A muckraking journalist, William Cowper Brand, started a newspaper, The Iconoclast, whose principle target was Baylor University.
The principle target cell for Huntington's disease is the striatal medium spiny neuron.
By directing SCFTIR activity towards the GFP, the mAID-nanobody can in principle target any protein for degradation regardless of their sequence, size and structure.
His principle target - the hype of the late 90s dot.com boom and the hypocrisy of the subsequent crash - is an obvious one, but Rosenzweig executes it with precision and detail.
Alternatively, drug delivery approaches using liposomes or other carriers can in principle target drugs to tumor tissue, tumor cells, or even compartments within tumor cells.
The data identify CYP6CM1vQ as a principle target for inhibitor design, aimed at inactivating insecticide-metabolizing P450s in natural insect pest populations.
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A forward numerical model of the TOF P-UPS is coupled to an inversion algorithm, based on the genetic optimization principle, targeting the determination of the orthotropic elastic parameters, and the quality of the inversion is demonstrated for synthetic data representative for composites.
First, he might invoke the volenti principle and insist that the harm principle targets only non-consensual harms.
And the third piece of theory is a moral principle targeted to promises directly, what Rawls call the Principle of Fidelity.
These different biochemical pathways can be, in principle, targeted pharmacologically, by prodrugs, for instance.
In principle, targeted HaploSeq is blind to genotyping and can be used to identify genetic variants de novo within the targeted loci.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com