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The synthesis of 2-HIB was successful at the experimental proof of principle stage.
It was found that the principle stage of the specimen wear takes place during the first 200 240 s of sliding independently of the applied speed; obviously, after this stage the intensity of wear decreases drastically.
* Significant at p < 0.001 in t-test ** In principle, stage indicates pathological stage (p-stage).
Hence, one of the main challenges for this field is to move beyond the proof of principle stage and consolidate the wealth of data being generated.
Consequently, transmission modeling rarely passes beyond the proof of principle stage, and yet it is required to help develop risk factor analysis for control programs.
First, however, technological and methodological advances are necessary for the blood transcriptome research field to move beyond the proof of principle stage.
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As can be seen in Figure 5, there are no notable differences in any of the principle stages when homozygous triple knockout males are compared with their heterozygous siblings (or wild-type).
It has taken researchers 60 years to get to this proof-of-principle stage.
Although the technique is still in the proof-of-principle stage, it "could be an immensely powerful tool in implementing conservation measures for the most at-risk bird populations with fine-scale precision," says Jeff Wells of the Boreal Songbird Initiative in Seattle, Washington.
Currently the Fe-TAML technology is somewhere between the proof-of-principle stage of investigation and the small-scale pilot plant stage of development, according to Horwitz.
We believe that the current challenge is to move gene therapy from the proof-of-principle stage into one of clinical efficacy.
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