Sentence examples for principle replacement from inspiring English sources
For full explication, see text Fig. 4 The Hannah Principle: replacement of Stölzel by Périnet valves.
Currently, the accepted ethical standards for the regulation of animal experimentation are provided by the 3R principle (Replacement, Reduction and Refinement).
However, due to ethical considerations according to the '3R' principle (replacement, reduction and refinement) in animal research [25], we considered this sample size to be sufficient to demonstrate the principle value of MTR for the detection of CAF.
According to the 3Rs principle (replacement, reduction and refinement) for experiments, the dilution of 1 10 was chosen instead of 1 5 so as to consume less serum from guinea pigs.
Therefore, combining transgenic rodent gene mutation assays 1 with repeated-dose toxicity studies would conform to the 3Rs principle (Replacement, Refinement, and Reduction) of animal use in laboratory experiments.
Scientists that use animal models in their work are guided by the 3Rs principles (replacement, reduction and refinement) that make them consider the impact of their work and ensure humane treatment of animals.
Nonclinical toxicology programs should be designed with consideration of ethical animal use and 3Rs principles (Replacement, Reduction and Refinement).
All animals were cared for and treated in accordance with the guidelines approved by Ethics Committee for Treatment of Laboratory Animals at NCNP, where three fundamental principles (replacement, reduction, and refinement) were also considered.
As a generic policy principle, substitution means the replacement of hazardous chemical substances and products by less hazardous alternatives [[5]].
Current animal ethics requirements emphasise the principle of replacement, refinement, and reduction (3Rs) in research using animals based on established guidelines [ 154].
It has become widely accepted that whenever animals are used in scientific procedures, the 3Rs principle of replacement, reduction and refinement described by William Russell and Rex Burch should be adhered to.
