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This could be in principle problematic for very soft materials or for extremely small nanoparticles whose geometry could change significantly due to tip-sample forces [28, 29].
First, interpreting trends in cause-specific mortality is in principle problematic because of changes in ICD revisions and coding practices over time.
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It is assumed that conditional hazards are constant within a single reporting interval (e.g. one year), which will in principle be problematic for conditions with high initial case-fatality, for example heart attack (or stroke).
But even basic principles are problematic.
As the possibility of a clear division between domestic and foreign affairs dissipates, the traditional tendency to picture the domestic arena as a privileged site for the realization of normative ideals and principles becomes problematic as well.
It's the broader application of the principle that's problematic.
But along with other planks of European judicial and police co-operation, it rests on the problematic principle of mutual recognition – that is, the belief that a Greek or Bulgarian judge is just as trustworthy and professional as a Swedish or British one.
Moreover, the appeal to the closure principle itself is problematic.
This problematic principle is formulated by Kant as follows: "If the conditioned is given, the absolutely unconditioned… is also given" (A308/B366).
Add the symbiotic relationships so prevalent in multi-cellular organisms, which require immune blindness to remain stable, the entire question of what is included as belonging to the organism and what is not leaves the "principle of inclusion" problematic.
Despite their disagreements on the level of antiquity that should be considered as the source of legitimate philosophical discourse, both agreed that principle was a problematic part of it and so should not be naively highlighted in metaphysical discussions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com